The Parrish lab is addressing key questions related to epilepsy and seizure disorders. We are particularly interested in mechanisms of endogenous inhibitory restraint and spontaneous seizure termination. We also seek to understand the role of a cellular event known as a cortical spreading depression in seizure termination, a phenomenon which is also associated with migraines. Finally, the lab is working to understand the mechanisms of prolonged seizure activity, known as status epilepticus, which is often pharmacoresistant. The lab uses electrophysiology, optogenetics, live network imaging, and computer programming to address our biological questions.
Biography
Dr. Parrish's research is focused on the study of epilepsy, including the mechanisms of seizure propagation and termination. He also studies a phenomenon known as cortical spreading depressions, which are associated with both seizure termination and migraines. Finally, he is working to understand the mechanisms of pharmacoresistant, prolonged seizure activity. The lab uses electrophysiology, optogenetics, live network imaging, and computer programming to address our biological questions.